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ea0011p760 | Steroids | ECE2006

Expression of oestrogen receptor related proteins beta occurs in multiple cell types within human endometrium during the normal menstrual cycle

Bombail V , Henderson T , Critchley HOD , Saunders PTK

Oestrogens are essential regulators of fertility in women. They induce changes in uterine cell function by binding to oestrogen receptors (ERs) two of which (ERα and ERß) have been identified. ERα and ERß share significant sequence homology with three other steroid receptor superfamily members that are known as oestrogen related receptors alpha (ERRα), beta (ERRß) and gamma (ERRγ). ERRs bind as monomers to the sequence TNAAGGTCA and as dimers...

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ea0039oc6.7 | Oral Communications 6 | BSPED2015

Standard and modified release hydrocortisone formulations: cortisol levels and patient preference

Park J , Henderson T , Leyland H , Das U , Didi M , Ramakrishnan R , Peak M , Blair J

Background: Cortisol profiles during treatment with standard hydrocortisone (StdHC) formulations are unphysiological. Some patients, with low cortisol levels between doses, experience symptomatic hypocortisolaemia and may benefit from modified release hydrocortisone (MRHC). Plenadren is a MRHC licensed for once daily dosing in adults.We offered Plenadren to patients with symptomatic hypocortisolaemia, documented to occur at times of low cortisol levels, ...

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Endocrine Abstracts

Expression of oestrogen receptor related proteins beta occurs in multiple cell types within human endometrium during the normal menstrual cycle

Standard and modified release hydrocortisone formulations: cortisol levels and patient preference

BiosciAbstracts